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J Virol. 2015 Jun;89(11):5752-5. doi: 10.1128/JVI.03187-14. Epub 2015 Mar 11.

Structure and Dynamics of the Native HIV-1 Env Trimer.

Author information

1
Department of Molecular Biology & Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA James.Munro@tufts.edu walther.mothes@yale.edu.
2
Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA James.Munro@tufts.edu walther.mothes@yale.edu.

Abstract

HIV-1/AIDS remains one of the worst pandemics in human history. Despite tremendous efforts, no effective vaccine has been found. Recent reports give new insights into the structure and dynamics of the HIV-1 Env trimer and renew hopes that a better understanding of Env will translate into new vaccine candidates and more-effective antiretroviral therapies.

PMID:
25762739
PMCID:
PMC4442439
DOI:
10.1128/JVI.03187-14
[Indexed for MEDLINE]
Free PMC Article

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