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Sci Rep. 2015 Mar 6;5:8813. doi: 10.1038/srep08813.

A potential interaction between COMT and MTHFR genetic variants in Han Chinese patients with bipolar II disorder.

Author information

1
Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
2
1] Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan [2] Department of Psychiatry, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan.
3
1] Department of Psychiatry, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan [2] Department of Neurology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
4
Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan.
5
Department of Psychiatry, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan.
6
Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
7
1] Department of Psychiatry, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan [2] Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan [3] Institute of Behavioral Medicine, college of medicine, National Cheng Kung University, Tainan, Taiwan [4] Addiction Research Center, National Cheng Kung University, Tainan, Taiwan [5] Center for Neuropsychiatric Research, National Health Research Institute, Miaoli, Taiwan.

Abstract

Bipolar II disorder (BP-II), characterized by recurrent dysregulation of mood, is a serious and chronic psychiatric illness. However, BP-II is commonly under-recognized, even in psychiatric settings. Because dopaminergic disturbance is thought to be involved in the development of bipolar disorder (BPD), it seems essential to investigate dopamine-related genes like the catechol-O-methyltransferase (COMT) gene, which are involved in dopamine metabolism, and the methylenetetrahydrofolate reductase (MTHFR) gene, which may affect COMT methylation and COMT function. The current study examined the association and interaction of the COMT Val158Met and MTHFR C677T variants with BP-II. Nine hundred seventy-eight participants were recruited: 531 with BP-II and 447 healthy controls. The genotypes of the COMT and MTHFR polymorphisms were determined using a polymerase chain reaction-restriction fragment length polymorphism analysis. Logistic regression analysis showed a significant interaction effect of the COMT Val158Met Val/Val genotype and the MTHFR C677T C/T + T/T genotype (P = 0.039) for the protective effect on the odds of developing BP-II. Our findings support preliminary evidence that the COMT and MTHFR genes interact in BP-II, and they imply the connection of both dopaminergic pathways and methylation pathways in the pathogenesis of BP-II.

PMID:
25744938
PMCID:
PMC4351536
DOI:
10.1038/srep08813
[Indexed for MEDLINE]
Free PMC Article

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