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Mol Cell. 2015 Feb 19;57(4):575-576. doi: 10.1016/j.molcel.2015.02.006.

Micro(RNA) managing by mTORC1.

Author information

1
Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla CA 92093, USA.
2
Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla CA 92093, USA. Electronic address: kuguan@ucsd.edu.

Abstract

In this issue of Molecular Cell, Ye et al. (2015) demonstrate that mTORC1 globally regulates miRNA biogenesis under nutrient-rich conditions via the E3 ubiquitin ligase Mdm2, which promotes Drosha degradation.

PMID:
25699705
PMCID:
PMC4378617
DOI:
10.1016/j.molcel.2015.02.006
[Indexed for MEDLINE]
Free PMC Article

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