Format

Send to

Choose Destination
Biomed Res Int. 2015;2015:246870. doi: 10.1155/2015/246870. Epub 2015 Jan 19.

CD8+ T-cells count in acute myocardial infarction in HIV disease in a predominantly male cohort.

Author information

1
Division of General Internal Medicine, University of Pittsburgh, UPMC Montefiore Hospital, Pittsburgh, PA 15213, USA.
2
Division of General Internal Medicine, University of Pittsburgh, UPMC Montefiore Hospital, Pittsburgh, PA 15213, USA ; Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA.
3
Yale School of Medicine, Yale University, New Haven, CT 06510, USA.
4
University of Vermont, Burlington, VT 05446, USA.
5
Department of Medicine, Hennepin County Medical Center, University of Minnesota, Minneapolis, MN 55415, USA.
6
VA Medical Center, Emory University School of Medicine, Atlanta, GA 30033, USA.
7
Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA ; VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA ; Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar.
8
Division of General Internal Medicine, University of Pittsburgh, UPMC Montefiore Hospital, Pittsburgh, PA 15213, USA ; VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA.
9
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA ; Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA.
10
Clinical Addiction Research and Education Unit, Boston University School of Medicine, Boston, MA 02118, USA ; Boston University School of Public Health, Boston, MA 02118, USA.
11
Department of General Internal Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN 37203, USA.
12
Department of Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA ; Department of Medicine, David Geffen School of Medicine, Los Angeles, CA 90095, USA.
13
Michael E. DeBakey VA Medical Center, Infectious Diseases Section, Baylor College of Medicine, Houston, TX 77030, USA.
14
VA North Texas Healthcare System, Dallas, TX 75216, USA ; Division of Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
15
Washington DC VA Medical Center, Washington, DC 20422, USA ; George Washington University Medical Center, Washington, DC 20037, USA.
16
Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA.
17
Department of Medicine, University of California, San Francisco, CA 94143, USA.
18
Veteran Affairs Connecticut Health Care System, West Haven Veterans Administration Medical Center, Yale School of Medicine, Yale University, New Haven, CT 06516, USA.
19
Cardiovascular Medicine Division, Vanderbilt University Medical Center, 2525 West End, Suite 300-A, Nashville, TN 37203, USA.

Abstract

Human Immunodeficiency Virus- (HIV-) infected persons have a higher risk for acute myocardial infarction (AMI) than HIV-uninfected persons. Earlier studies suggest that HIV viral load, CD4+ T-cell count, and antiretroviral therapy are associated with cardiovascular disease (CVD) risk. Whether CD8+ T-cell count is associated with CVD risk is not clear. We investigated the association between CD8+ T-cell count and incident AMI in a cohort of 73,398 people (of which 97.3% were men) enrolled in the U.S. Veterans Aging Cohort Study-Virtual Cohort (VACS-VC). Compared to uninfected people, HIV-infected people with high baseline CD8+ T-cell counts (>1065 cells/mm3) had increased AMI risk (adjusted HR=1.82, P<0.001, 95% CI: 1.46 to 2.28). There was evidence that the effect of CD8+ T-cell tertiles on AMI risk differed by CD4+ T-cell level: compared to uninfected people, HIV-infected people with CD4+ T-cell counts≥200 cells/mm3 had increased AMI risk with high CD8+ T-cell count, while those with CD4+ T-cell counts<200 cells/mm3 had increased AMI risk with low CD8+ T-cell count. CD8+ T-cell counts may add additional AMI risk stratification information beyond that provided by CD4+ T-cell counts alone.

PMID:
25688354
PMCID:
PMC4320893
DOI:
10.1155/2015/246870
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Hindawi Limited Icon for PubMed Central
Loading ...
Support Center