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Cancer Discov. 2015 Feb;5(2):109-11. doi: 10.1158/2159-8290.CD-15-0013.

Sweets for a bitter end: lung cancer cell-surface protein glycosylation mediates metastatic colonization.

Author information

1
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.
2
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut. Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut. don.nguyen@yale.edu.

Abstract

Glycosylation is one of the most predominant forms of cell-surface protein modifications, yet its deregulation in cancer and contribution to tumor microenvironment interactions remain poorly understood. In this issue of Cancer Discovery, Reticker-Flynn and Bhatia characterize an enzymatic switch in lung cancer cells that triggers aberrant surface protein glycosylation patterns, adhesion to lectins on the surface of inflammatory cells, and subsequent metastatic colonization of the liver.

PMID:
25656895
PMCID:
PMC4340588
DOI:
10.1158/2159-8290.CD-15-0013
[Indexed for MEDLINE]
Free PMC Article

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