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Curr Opin Pharmacol. 2015 Feb;20:102-8. doi: 10.1016/j.coph.2014.11.011. Epub 2014 Dec 17.

Synaptic localization of neurotransmitter receptors: comparing mechanisms for AMPA and GABAA receptors.

Author information

1
Program in Cellular Neuroscience, Neurodegeneration and Repair (CNNR), Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA.
2
Program in Cellular Neuroscience, Neurodegeneration and Repair (CNNR), Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address: Susumu.Tomita@yale.edu.

Abstract

Ionotropic neurotransmitter receptors mediate fast synaptic transmission by localizing at postsynapses. Changes in receptor number at synapses induce synaptic plasticity. Thus, mechanisms for the synaptic localization of receptors in basal transmission and synaptic plasticity have been investigated extensively. Recent findings reveal that synaptic localization of tetrameric AMPA receptors in basal transmission requires the PDZ binding of TARP auxiliary subunits, which modulate receptor properties and pharmacology. On the other hand, pentameric GABAA receptors require multiple receptor subunits for their synaptic localization in basal transmission. AMPA receptors seem to utilize distinct mechanisms for basal synaptic localization and synaptic insertion during plasticity. Revealing precise mechanisms for receptor synaptic localization may establish new approaches to control synaptic transmission.

PMID:
25529200
PMCID:
PMC4318715
DOI:
10.1016/j.coph.2014.11.011
[Indexed for MEDLINE]
Free PMC Article
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