Format

Send to

Choose Destination
See comment in PubMed Commons below
J Autism Dev Disord. 2015 Jun;45(6):1905-14. doi: 10.1007/s10803-014-2344-y.

Brief report: Anomalous neural deactivations and functional connectivity during receptive language in autism spectrum disorder: a functional MRI study.

Author information

1
Brain Function Laboratory, Departments of Psychiatry and Neurobiology, Yale University School of Medicine, 300 George Street, Suite 902, New Haven, CT, 06511, USA.

Abstract

Neural mechanisms that underlie language disability in autism spectrum disorder (ASD) have been associated with reduced excitatory processes observed as positive blood oxygen level dependent (BOLD) responses. However, negative BOLD responses (NBR) associated with language and inhibitory processes have been less studied in ASD. In this study, functional magnetic resonance imaging showed that the NBR in ASD participants was reduced during passive listening to spoken narratives compared to control participants. Further, functional connectivity between the superior temporal gyrus and regions that exhibited a NBR during receptive language in control participants was increased in ASD participants. These findings extend models for receptive language disability in ASD to include anomalous neural deactivations and connectivity consistent with reduced or poorly modulated inhibitory processes.

PMID:
25526952
PMCID:
PMC4441908
DOI:
10.1007/s10803-014-2344-y
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Support Center