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J Am Chem Soc. 2014 Dec 31;136(52):18034-43. doi: 10.1021/ja509513c. Epub 2014 Dec 16.

Chemically synthesized molecules with the targeting and effector functions of antibodies.

Author information

1
Department of Chemistry, Yale University , 225 Prospect Street, New Haven, Connecticut 06511, United States.

Abstract

This article reports the design, synthesis, and evaluation of a novel class of molecules of intermediate size (approximately 7000 Da), which possess both the targeting and effector functions of antibodies. These compounds—called synthetic antibody mimics targeting prostate cancer (SyAM-Ps)—bind simultaneously to prostate-specific membrane antigen and Fc gamma receptor I, thus eliciting highly selective cancer cell phagocytosis. SyAMs have the potential to combine the advantages of both small-molecule and biologic therapies, and may address many drawbacks associated with available treatments for cancer and other diseases.

PMID:
25514603
PMCID:
PMC4291750
DOI:
10.1021/ja509513c
[Indexed for MEDLINE]
Free PMC Article

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