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PLoS One. 2014 Dec 12;9(12):e114913. doi: 10.1371/journal.pone.0114913. eCollection 2014.

The cardiopulmonary effects of ambient air pollution and mechanistic pathways: a comparative hierarchical pathway analysis.

Author information

1
Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, United States of America.
2
Duke University, Nicholas School of the Environment and Duke Global Health Institute, Durham, North Carolina, United States of America.
3
University of Southern California, Keck School of Medicine, Department of Preventive Medicine, Los Angeles, California, United States of America.
4
Environmental and Occupational Health Sciences Institute, Rutgers Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, United States of America.
5
University of Rochester, School of Medicine and Dentistry, Department of Public Health Sciences. Rochester, New York, United States of America.
6
Peking University, State Key Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, and the Center for Environment and Health, Beijing, China.
7
Peking University, School of Public Health, Department of Occupational and Environmental Health and Institute of Environmental Medicine, Beijing, China.
8
Peking University First Hospital, Department of Pulmonary Medicine, Beijing, China.
9
Peking University Health Sciences Center, Department of Immunology, Beijing, China.
10
Peking University First Hospital, Department of Hematology, Beijing, China.
11
Rutgers School of Public Health, Department of Biostatistics, Piscataway, New Jersey, United States of America.
12
Rutgers School of Dentistry, Center for Pharmacogenomics and Complex Disease, Newark, New Jersey, United States of America.

Abstract

Previous studies have investigated the associations between exposure to ambient air pollution and biomarkers of physiological pathways, yet little has been done on the comparison across biomarkers of different pathways to establish the temporal pattern of biological response. In the current study, we aim to compare the relative temporal patterns in responses of candidate pathways to different pollutants. Four biomarkers of pulmonary inflammation and oxidative stress, five biomarkers of systemic inflammation and oxidative stress, ten parameters of autonomic function, and three biomarkers of hemostasis were repeatedly measured in 125 young adults, along with daily concentrations of ambient CO, PM2.5, NO2, SO2, EC, OC, and sulfate, before, during, and after the Beijing Olympics. We used a two-stage modeling approach, including Stage I models to estimate the association between each biomarker and pollutant over each of 7 lags, and Stage II mixed-effect models to describe temporal patterns in the associations when grouping the biomarkers into the four physiological pathways. Our results show that candidate pathway groupings of biomarkers explained a significant amount of variation in the associations for each pollutant, and the temporal patterns of the biomarker-pollutant-lag associations varied across candidate pathways (p<0.0001) and were not linear (from lag 0 to lag 3: p = 0.0629, from lag 3 to lag 6: p = 0.0005). These findings suggest that, among this healthy young adult population, the pulmonary inflammation and oxidative stress pathway is the first to respond to ambient air pollution exposure (within 24 hours) and the hemostasis pathway responds gradually over a 2-3 day period. The initial pulmonary response may contribute to the more gradual systemic changes that likely ultimately involve the cardiovascular system.

PMID:
25502951
PMCID:
PMC4264846
DOI:
10.1371/journal.pone.0114913
[Indexed for MEDLINE]
Free PMC Article
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