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Cell Rep. 2014 Dec 24;9(6):2139-51. doi: 10.1016/j.celrep.2014.11.026. Epub 2014 Dec 11.

Diversity of cortical interneurons in primates: the role of the dorsal proliferative niche.

Author information

1
Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA; Institute of Medical and Clinical Biochemistry, School of Medicine, University of Belgrade, Pasterova 2, 11000 Belgrade, Serbia.
2
Department of Neurobiology, Yale University School of Medicine and Kavli Institute for Neuroscience, New Haven, CT 06510, USA.
3
Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA.
4
Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
5
Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA; Experimental Neurophysiology, German Center for Neurodegenerative Diseases, 53175 Bonn, Germany.
6
The Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4318, USA.
7
Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA. Electronic address: nzecevic@neuron.uchc.edu.

Abstract

Evolutionary elaboration of tissues starts with changes in the genome and location of the stem cells. For example, GABAergic interneurons of the mammalian neocortex are generated in the ventral telencephalon and migrate tangentially to the neocortex, in contrast to the projection neurons originating in the ventricular/subventricular zone (VZ/SVZ) of the dorsal telencephalon. In human and nonhuman primates, evidence suggests that an additional subset of neocortical GABAergic interneurons is generated in the cortical VZ and a proliferative niche, the outer SVZ. The origin, magnitude, and significance of this species-specific difference are not known. We use a battery of assays applicable to the human, monkey, and mouse organotypic cultures and supravital tissue to identify neuronal progenitors in the cortical VZ/SVZ niche that produce a subset of GABAergic interneurons. Our findings suggest that these progenitors constitute an evolutionary novelty contributing to the elaboration of higher cognitive functions in primates.

PMID:
25497090
PMCID:
PMC4306459
DOI:
10.1016/j.celrep.2014.11.026
[Indexed for MEDLINE]
Free PMC Article
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