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Ann Epidemiol. 2015 Jan;25(1):46-54.e3. doi: 10.1016/j.annepidem.2014.10.011. Epub 2014 Oct 16.

Low-to-moderate prenatal alcohol consumption and the risk of selected birth outcomes: a prospective cohort study.

Author information

1
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT.
2
Center for Perinatal, Pediatric and Environmental Epidemiology, Yale University School of Public Health, New Haven, CT.
3
Department of Community Health/Epidemiology, Brown University School of Medicine, Providence, RI.
4
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT; Center for Perinatal, Pediatric and Environmental Epidemiology, Yale University School of Public Health, New Haven, CT. Electronic address: michael.bracken@yale.edu.

Abstract

PURPOSE:

To estimate whether low-to-moderate prenatal alcohol exposure is associated with selected birth outcomes.

METHODS:

Low-to-moderate prenatal alcohol drinking and effects on low birthweight, preterm delivery, intrauterine growth restriction, and selected neonatal outcomes were evaluated among 4496 women and singleton infants. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable logistic regression, controlling for confounding variables.

RESULTS:

Early pregnancy drinking was associated with reduced odds of low birthweight, OR, 0.66 (95% CI, 0.46-0.96) and birth length less than 10th percentile, OR, 0.74 (95% CI, 0.56-0.97). Drinking during the first 3 months showed lower odds for birth length and head circumference less than 10th percentile, OR, 0.56 (95% CI, 0.36-0.87) and OR, 0.69 (95% CI, 0.50-0.96), respectively. Third trimester drinking was associated with lower odds for low birthweight, OR, 0.56 (95% CI, 0.34-0.94) and preterm delivery, OR, 0.60 (95% CI, 0.42-0.87).

CONCLUSIONS:

Our results suggest low-to-moderate alcohol exposure during early and late gestation is not associated with increased risk of low birthweight, preterm delivery, intrauterine growth restriction, and most selected perinatal outcomes.

KEYWORDS:

Alcohol; Birth outcomes; IUGR; Low birthweight; Preterm delivery

PMID:
25453352
PMCID:
PMC4255148
DOI:
10.1016/j.annepidem.2014.10.011
[Indexed for MEDLINE]
Free PMC Article

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