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Neurosci Lett. 2015 Jan 1;584:276-81. doi: 10.1016/j.neulet.2014.10.039. Epub 2014 Nov 1.

Intravenous mesenchymal stem cell administration exhibits therapeutic effects against 6-hydroxydopamine-induced dopaminergic neurodegeneration and glial activation in rats.

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Department of Neurology, School of Medicine, Sapporo Medical University, Sapporo, Japan.
Department of Neurology, Yale University School of Medicine, New Haven, USA.
Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University, Sapporo, Japan.
Department of Neurology, School of Medicine, Sapporo Medical University, Sapporo, Japan. Electronic address:

Erratum in

  • Neurosci Lett. 2015 Feb 5;587:5. Iwahara, Naoyuki [corrected to Iwahara, Naotoshi].


To explore a novel therapy against Parkinson's disease (PD), we evaluated the therapeutic effects of human bone marrow-derived mesenchymal stem cells (hBM-MSCs), pluripotent stromal cells with secretory potential of various neurotrophic and anti-inflammatory factors, in a hemi-parkinsonian rat model. The unilateral intrastriatal 6-hydroxydopamine (6-OHDA)-lesioned rats were injected hBM-MSCs (1.0 × 10(7)cells) or PBS intravenously 16 days after lesioning. Administration of hBM-MSCs inhibited methamphetamine-stimulated rotational behavior at 7, 14, 21 and 28 days after transplantation. Immunohistochemical analysis also showed that number of TH-positive neurons in the substantia nigra pars compacta was significantly preserved in hBM-MSCs-transplanted rats compared to sham-operated rats, whereas the immunoreactivity of ionized calcium binding adaptor molecule 1 was markedly inhibited. In this study, we demonstrated the therapeutic effects of intravenous hBM-MSCs administration in parkinsonian model rats presenting distinct parkinsonian phenotype at 16 days after 6-OHDA lesioning. The favorable findings raise the possibility that hBM-MSCs could be a novel therapeutic option to promote survival of dopaminergic neurons in PD.


6-Hydroxydopamine; Anti-inflammatory; Mesenchymal stem cell; Neuroprotection; Parkinson's disease

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