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J Thorac Oncol. 2014 Sep;9(9 Suppl 2):S73-80. doi: 10.1097/JTO.0000000000000303.

The IASLC/ITMIG Thymic Epithelial Tumors Staging Project: proposals for the T Component for the forthcoming (8th) edition of the TNM classification of malignant tumors.

Collaborators (196)

Goldstraw P, Rami-Porta R, Asamura H, Ball D, MacCallum P, Beer D, Beyruti R, Bolejack V, Chansky K, Crowley J, Detterbeck F, Eberhardt WE, Edwards J, Galateau-Sallé F, Giroux D, Gleeson F, Groome P, Huang J, Kennedy C, Kim J, Kim YT, Kingsbury L, Kondo H, Krasnik M, Kubota K, Lerut A, Lyons G, Marino M, Marom E, van Meerbeeck J, Mitchell A, Nakano T, Nicholson AG, Brompton R, Nowak A, Peake M, Rice T, Rosenzweig K, Ruffini E, Rusch V, Saijo N, Van Schil P, Sculier JP, Shemanski L, Stratton K, Suzuki K, Tachimori Y, Thomas CF Jr, Travis W, Tsao MS, Turrisi A, Vansteenkiste J, Watanabe H, Wu YL, Falkson C, Filosso PL, Giaccone G, Kondo K, Lucchi M, Okumura M, Baas P, Erasmus J, Hasegawa S, Inai K, Kernstine K, Kindler H, Krug L, Nackaerts K, Pass H, Rice D, Blackstone E, Call Caja S, Ahmad U, Detterbeck F, Girard N, Haam SJ, Bae MK, Gomez DR, Marom E, Van Schil P, Ströbel P, Marx A, Saita S, Wakelee H, Bertolaccini L, Vallieres E, Scott W, Su S, Park B, Marks J, Khella S, Shen R, Rosenberg M, Rosenberg M, Tomulescu V, Huang J, Foroulis C, Lang-Lazdunski L, Billè A, Maessen JG, Keijzers M, van Veer H, Wright C, Marino M, Facciolo F, Palmieri G, Buonerba C, Ferguson M, Marulli G, Lucchi M, Loehrer P, Kalkat M, Rohrberg K, Daugaard G, Toker A, Erus S, Kimmich M, Brunelli A, Refai M, Nicholson A, Lim E, Park IK, Wagner J, Tieu B, Fang W, Zhang J, Yu Z, Han Y, Li Y, Chen K, Chen G, Okumura M, Fujii Y, Asamura H, Nagai K, Nakajima J, Ikeda N, Haraguchi S, Onuki T, Suzuki K, Yoshino I, Tsuchida M, Takahashi S, Yokoi K, Hanyuda M, Niwa H, Date H, Maniwa Y, Miyoshi S, Kondo K, Iwasaki A, Okamoto T, Nagayasu T, Tanaka F, Suzuki M, Yoshida K, Okuma Y, Horio H, Matsumura A, Higashiyama M, Suehisa H, Onuki T, Sano Y, Kondo K, Al Kattan K, Cerfolio R, Gebitekin C, de Antonio D, Kernstine KH, Altorki N, Novoa N, Ruffini E, Filosso PL, Saita S, Scarci M, Voltolini L, Weder W, Zurek W, Arame A, Casadio C, Carbognani P, Donati G, Keshavjee S, Klepetko W, Moser B, Lequaglie C, Liberman M, Mancuso M, Nosotti M, Spaggiari L, Thomas PA, Rendina E, Venuta F, Anile M, Schützner J, Rocco G.

Author information

1
*Pathology, Royal Brompton Hospital, London, United Kingdom; †Thoracic Surgery, Yale University, New Haven, Connecticut; ‡Pathology, Regina Elena National Cancer Institute, Rome, Italy; §Thoracic Surgery, Samsung Medical Center, Seoul, South Korea; ‖Biostatistics, Cancer Research And Biostatistics, Seattle, Washington; ¶Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan; #Radiation Oncology, Queen's University, Ontario, Canada; **Thoracic Surgery, University of Torino, Torino, Italy; ††Medical Oncology, Georgetown University, Washington, District of Columbia; ‡‡Thoracic Surgery, Sloan Kettering Cancer Center, New York, New York; §§Thoracic Surgery, University of Tokushima, Tokushima, Japan; ‖‖Thoracic Surgery, University of Pisa, Pisa, Italy; ¶¶Radiology, MD Anderson Cancer Center, Houston, Texas; ##Thoracic Surgery, Osaka University, Osaka, Japan; and ***Thoracic Surgery, Antwerp University Hospital, Antwerp, Belgium.

Abstract

Despite longstanding recognition of thymic epithelial neoplasms, there is no official American Joint Committee on Cancer/Union for International Cancer Control stage classification. This article summarizes proposals for classification of the T component of stage classification for use in the 8th edition of the tumor, node, metastasis classification for malignant tumors. This represents the output of the International Association for the Study of Lung Cancer and the International Thymic Malignancies Interest Group Staging and Prognostics Factor Committee, which assembled and analyzed a worldwide database of 10,808 patients with thymic malignancies from 105 sites. The committee proposes division of the T component into four categories, representing levels of invasion. T1 includes tumors localized to the thymus and anterior mediastinal fat, regardless of capsular invasion, up to and including infiltration through the mediastinal pleura. Invasion of the pericardium is designated as T2. T3 includes tumors with direct involvement of a group of mediastinal structures either singly or in combination: lung, brachiocephalic vein, superior vena cava, chest wall, and phrenic nerve. Invasion of more central structures constitutes T4: aorta and arch vessels, intrapericardial pulmonary artery, myocardium, trachea, and esophagus. Size did not emerge as a useful descriptor for stage classification. This classification of T categories, combined with a classification of N and M categories, provides a basis for a robust tumor, node, metastasis classification system for the 8th edition of American Joint Committee on Cancer/Union for International Cancer Control stage classification.

PMID:
25396315
DOI:
10.1097/JTO.0000000000000303
[Indexed for MEDLINE]
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