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J Gerontol A Biol Sci Med Sci. 2015 Feb;70(2):216-22. doi: 10.1093/gerona/glu099. Epub 2014 Nov 11.

A physical activity intervention to treat the frailty syndrome in older persons-results from the LIFE-P study.

Author information

1
Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France. Institut national de la santé et de la recherche médicale (UMR1027), Université de Toulouse III Paul Sabatier, France. macesari@gmail.com.
2
Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France. Institut national de la santé et de la recherche médicale (UMR1027), Université de Toulouse III Paul Sabatier, France.
3
Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston Salem, North Carolina.
4
Department of Epidemiology, University of Pittsburgh, Pennsylvania.
5
Department of Statistics, University of Florida, Gainesville.
6
Department of Health Research and Policy and Stanford Prevention Research Center, Stanford University, Palo Alto, California.
7
Department of Aging and Geriatric Research, Institute on Aging, University of Florida, Gainesville.
8
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge.
9
Department of Medicine, Yale University, New Haven, Connecticut.

Abstract

BACKGROUND:

The frailty syndrome is as a well-established condition of risk for disability. Aim of the study is to explore whether a physical activity (PA) intervention can reduce prevalence and severity of frailty in a community-dwelling elders at risk of disability.

METHODS:

Exploratory analyses from the Lifestyle Interventions and Independence for Elders pilot, a randomized controlled trial enrolling 424 community-dwelling persons (mean age=76.8 years) with sedentary lifestyle and at risk of mobility disability. Participants were randomized to a 12-month PA intervention versus a successful aging education group. The frailty phenotype (ie, ≥3 of the following defining criteria: involuntary weight loss, exhaustion, sedentary behavior, slow gait speed, poor handgrip strength) was measured at baseline, 6 months, and 12 months. Repeated measures generalized linear models were conducted.

RESULTS:

A significant (p = .01) difference in frailty prevalence was observed at 12 months in the PA intervention group (10.0%; 95% confidence interval = 6.5%, 15.1%), relative to the successful aging group (19.1%; 95% confidence interval = 13.9%,15.6%). Over follow-up, in comparison to successful aging participants, the mean number of frailty criteria in the PA group was notably reduced for younger subjects, blacks, participants with frailty, and those with multimorbidity. Among the frailty criteria, the sedentary behavior was the one most affected by the intervention.

CONCLUSIONS:

Regular PA may reduce frailty, especially in individuals at higher risk of disability. Future studies should be aimed at testing the possible benefits produced by multidomain interventions on frailty.

KEYWORDS:

Clinical trials.; Frailty; Physical activity; Physical function; Successful aging

PMID:
25387728
PMCID:
PMC4311184
DOI:
10.1093/gerona/glu099
[Indexed for MEDLINE]
Free PMC Article

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