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Cold Spring Harb Perspect Biol. 2014 Oct 23;7(1):a016345. doi: 10.1101/cshperspect.a016345.

Inflammation and the blood microvascular system.

Author information

1
Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8089.
2
Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8089.

Abstract

Acute and chronic inflammation is associated with changes in microvascular form and function. At rest, endothelial cells maintain a nonthrombogenic, nonreactive surface at the interface between blood and tissue. However, on activation by proinflammatory mediators, the endothelium becomes a major participant in the generation of the inflammatory response. These functions of endothelium are modified by the other cell populations of the microvessel wall, namely pericytes, and smooth muscle cells. This article reviews recent advances in understanding the roles played by microvessels in inflammation.

PMID:
25384307
PMCID:
PMC4292166
DOI:
10.1101/cshperspect.a016345
[Indexed for MEDLINE]
Free PMC Article

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