Format

Send to

Choose Destination
See comment in PubMed Commons below
Dev Psychobiol. 2015 Jan;57(1):131-9. doi: 10.1002/dev.21265. Epub 2014 Nov 7.

Preliminary associations between childhood neglect, MIF, and cortisol: potential pathways to long-term disease risk.

Author information

1
Child Study Center, Yale School of Medicine, New Haven, CT.

Abstract

The study examined Hypothalamus-Pituitary-Adrenal (HPA) axis and inflammatory signaling in 206 youth with histories of prenatal drug exposure and self-reported histories of maltreatment. Youth with histories of severe neglect showed elevated levels of cortisol, the end product of the HPA axis, in comparison to youth with lower or minimal levels of neglect. Histories of severe neglect also were associated with increased levels of Macrophage Migration Inhibitory Factor (MIF), a cytokine known to be intricately involved in HPA axis regulation. Salivary MIF levels also were positively associated with youth age and prenatal drug exposure. These MIF and cortisol alterations may signal pathophysiological disruptions in the neuro-endocrine and immune systems, which may lead to trajectories of increased disease risk among vulnerable youth. Our findings also provide preliminary support for the validity and reliability of a noninvasive salivary assessment of MIF.

KEYWORDS:

HPA axis; adolescent; immune system; parental care; stress

PMID:
25380347
PMCID:
PMC4337818
DOI:
10.1002/dev.21265
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center