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Curr Top Membr. 2014;74:113-33. doi: 10.1016/B978-0-12-800181-3.00005-1.

Temperature sensitivity of two-pore (K2P) potassium channels.

Author information

  • 1Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.
  • 2Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA; Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale School of Medicine, New Haven, CT, USA.

Abstract

At normal body temperature, the two-pore potassium channels TREK-1 (K2P2.1/KCNK2), TREK-2 (K2P10.1/KCNK10), and TRAAK (K2P4.1/KCNK2) regulate cellular excitability by providing voltage-independent leak of potassium. Heat dramatically potentiates K2P channel activity and further affects excitation. This review focuses on the current understanding of the physiological role of heat-activated K2P current, and discusses the molecular mechanism of temperature gating in TREK-1, TREK-2, and TRAAK.

KEYWORDS:

Ion channel; K(2P); Potassium channel; TRAAK; TREK-1; TREK-2; Thermosensitivity; Thermotransduction; Two-pore

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