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J Biol Chem. 2014 Nov 14;289(46):31673-81. doi: 10.1074/jbc.R114.612697. Epub 2014 Oct 10.

Piezo proteins: regulators of mechanosensation and other cellular processes.

Author information

  • 1From the Department of Cellular and Molecular Physiology.
  • 2From the Department of Cellular and Molecular Physiology, Yale Program in Cellular Neuroscience, Neurodegeneration and Repair, and.
  • 3Departments of Pediatrics, Pathology, and Genetics, Yale University School of Medicine, New Haven, Connecticut 06520 patrick.gallagher@yale.edu.

Abstract

Piezo proteins have recently been identified as ion channels mediating mechanosensory transduction in mammalian cells. Characterization of these channels has yielded important insights into mechanisms of somatosensation, as well as other mechano-associated biologic processes such as sensing of shear stress, particularly in the vasculature, and regulation of urine flow and bladder distention. Other roles for Piezo proteins have emerged, some unexpected, including participation in cellular development, volume regulation, cellular migration, proliferation, and elongation. Mutations in human Piezo proteins have been associated with a variety of disorders including hereditary xerocytosis and several syndromes with muscular contracture as a prominent feature.

KEYWORDS:

Arthrogryposis; Genetic Disease; Gordon Syndrome; Hereditary Xerocytosis; Ion Channel; Mechanotransduction; Membrane Protein; Neuron; Piezo1; Piezo2; Somatosensation

PMID:
25305018
PMCID:
PMC4231648
DOI:
10.1074/jbc.R114.612697
[PubMed - indexed for MEDLINE]
Free PMC Article
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