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J Cell Mol Med. 2015 Jan;19(1):249-56. doi: 10.1111/jcmm.12433. Epub 2014 Oct 6.

Endometrial stem cell transplantation in MPTP- exposed primates: an alternative cell source for treatment of Parkinson's disease.

Author information

1
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA.

Abstract

Parkinson's disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra. Cell-replacement therapies have emerged as a promising strategy to slow down or replace neuronal loss. Compared to other stem cell types, endometrium-derived stem cells (EDSCs) are an attractive source of stem cells for cellular therapies because of their ease of collection and vast differentiation potential. Here we demonstrate that endometrium-derived stem cells may be transplanted into an MPTP exposed monkey model of PD. After injection into the striatum, endometrium-derived stem cells engrafted, exhibited neuron-like morphology, expressed tyrosine hydroxylase (TH) and increased the numbers of TH positive cells on the transplanted side and dopamine metabolite concentrations in vivo. Our results suggest that endometrium-derived stem cells may provide a therapeutic benefit in the primate model of PD and may be used in stem cell based therapies.

KEYWORDS:

MPTP; Parkinson disease; adult stem cells; endometrium; mesenchymal stem cells; neurodegenerative diseases; stem cells; transplantation

PMID:
25283241
PMCID:
PMC4288367
DOI:
10.1111/jcmm.12433
[Indexed for MEDLINE]
Free PMC Article
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