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Clin J Am Soc Nephrol. 2015 Sep 4;10(9):1626-35. doi: 10.2215/CJN.00730114. Epub 2014 Oct 3.

Chemical and Physical Sensors in the Regulation of Renal Function.

Author information

  • 1Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and.
  • 2Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut michael.caplan@yale.edu.

Abstract

In order to assess the status of the volume and composition of the body fluid compartment, the kidney monitors a wide variety of chemical and physical parameters. It has recently become clear that the kidney's sensory capacity extends well beyond its ability to sense ion concentrations in the forming urine. The kidney also keeps track of organic metabolites derived from a surprising variety of sources and uses a complex interplay of physical and chemical sensing mechanisms to measure the rate of fluid flow in the nephron. Recent research has provided new insights into the nature of these sensory mechanisms and their relevance to renal function.

KEYWORDS:

cell and transport physiology; cell signaling; renal physiology

PMID:
25280495
PMCID:
PMC4559500
DOI:
10.2215/CJN.00730114
[PubMed - indexed for MEDLINE]
Free PMC Article
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