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Mol Cell. 2014 Oct 2;56(1):18-27. doi: 10.1016/j.molcel.2014.09.012.

Posttranscriptional regulation of gene expression by Piwi proteins and piRNAs.

Author information

1
Yale Stem Cell Center and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06519, USA. Electronic address: toshwatatoshiakiwatanabe@gmail.com.
2
Yale Stem Cell Center and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06519, USA. Electronic address: haifan.lin@yale.edu.

Abstract

Piwi proteins and Piwi-interacting RNAs (piRNAs) are essential for gametogenesis, embryogenesis, and stem cell maintenance in animals. Piwi proteins act on transposon RNAs by cleaving the RNAs and by interacting with factors involved in RNA regulation. Additionally, piRNAs generated from transposons and psuedogenes can be used by Piwi proteins to regulate mRNAs at the posttranscriptional level. Here we discuss piRNA biogenesis, recent findings on posttranscriptional regulation of mRNAs by the piRNA pathway, and the potential importance of this posttranscriptional regulation for a variety of biological processes such as gametogenesis, developmental transitions, and sex determination.

PMID:
25280102
PMCID:
PMC4185416
DOI:
10.1016/j.molcel.2014.09.012
[Indexed for MEDLINE]
Free PMC Article
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