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Semin Cell Dev Biol. 2015 Jan;37:66-72. doi: 10.1016/j.semcdb.2014.09.021. Epub 2014 Sep 26.

Mining the function of protein tyrosine phosphatases in health and disease.

Author information

1
Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.
2
Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA; Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, New Haven, CT, USA. Electronic address: anton.bennett@yale.edu.

Abstract

Protein tyrosine phosphatases (PTPs) play a crucial role in the regulation of human health and it is now clear that PTP dysfunction is causal to a variety of human diseases. Research in the PTP field has accelerated dramatically over the last decade fueled by cutting-edge technologies in genomic and proteomic techniques. This system-wide non-biased approach when applied to the discovery of PTP function has led to the elucidation of new and unanticipated roles for the PTPs. These discoveries, driven by genomic and proteomic approaches, have uncovered novel PTP findings that range from those that describe fundamental cell signaling mechanisms to implications for PTPs as novel therapeutic targets for the treatment of human disease. This review will discuss how new PTP functions have been uncovered through studies that have utilized genomic and proteomic technologies and strategies.

KEYWORDS:

Genomics; Phosphorylation; Protein tyrosine phosphatases; Proteomics; Signal transduction; Substrates

PMID:
25263013
PMCID:
PMC4339398
DOI:
10.1016/j.semcdb.2014.09.021
[Indexed for MEDLINE]
Free PMC Article

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