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J Asthma. 2015 Apr;52(3):232-9. doi: 10.3109/02770903.2014.966913. Epub 2014 Oct 8.

SPINK5 and ADRB2 haplotypes are risk factors for asthma in Mexican pediatric patients.

Author information

1
Escuela Superior de Medicina, Instituto Politecnico Nacional , México City , Mexico .

Abstract

BACKGROUND:

Asthma is one of the most common respiratory diseases worldwide, and the complexity of its etiology has been widely documented. Chromosome 5q31-33 is one of the main loci implicated in asthma and asthma-related traits. IL13, CD14 and ADRB2, which are located in this risk locus, are among the genes most strongly associated with asthma susceptibility.

OBJECTIVES:

This study evaluated whether single-nucleotide polymorphisms or haplotypes at 5q31-33 conferred risk for asthma in Mexican-Mestizo pediatric patients.

METHODS:

We performed a case-controlled study including 851 individuals, 421 of them affected with childhood-onset asthma and 430 ethnically matched unaffected subjects. We used the TaqMan Allelic Discrimination Assay to genotype 20 single-nucleotide polymorphisms within IL5, RAD50, IL13, IL4, CD14, SPINK5, HTR4, ADRB2 and IL12B.

RESULTS:

Although no association was detected for any risk allele, three SPINK5 haplotypes (GGCT: p = 6 × 10(-6); AATC: p = 0.0001; AGTT: p = 0.0001) and five ADRB2 haplotypes (AGGACC: p = 0.0014; AGGAAG: p = 0.0002; TGAGAG: p = 0.0001; AGGAAC: p = 0.0002; AAGGAG: p = 0.003) were associated with asthma. Notably, the AGTT SPINK5 haplotype exhibited a male gender-dependent association (p = 7.6 × 10(-5)).

CONCLUSION:

Our results suggest that SPINK5 and ADRB2 haplotypes might play a role in the susceptibility to childhood-onset asthma.

KEYWORDS:

5q31-33 locus; ADRB2; SPINK5; asthma; case-controlled study; pediatric patients

PMID:
25233048
DOI:
10.3109/02770903.2014.966913
[Indexed for MEDLINE]

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