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Clin Gastroenterol Hepatol. 2015 Mar;13(3):561-568.e1. doi: 10.1016/j.cgh.2014.08.039. Epub 2014 Sep 15.

Effect of weight loss on magnetic resonance imaging estimation of liver fat and volume in patients with nonalcoholic steatohepatitis.

Author information

1
Division of Internal Medicine, Department of Medicine, University of California San Diego Health System, La Jolla, California.
2
Division of Gastroenterology, Department of Medicine, University of California San Diego Health System, La Jolla, California.
3
Department of Pathology, University of California San Diego Health System, La Jolla, California.
4
Liver Imaging Group, Department of Radiology, University of California San Diego Health System, La Jolla, California.
5
Department of Surgery, University of California San Diego Health System, La Jolla, California.
6
Division of Gastroenterology, Department of Medicine, University of California San Diego Health System, La Jolla, California; Department of Surgery, University of California San Diego Health System, La Jolla, California.
7
Division of Gastroenterology, Department of Medicine, University of California San Diego Health System, La Jolla, California; Division of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego Health System, La Jolla, California. Electronic address: roloomba@ucsd.edu.

Abstract

BACKGROUND & AIMS:

Little is known about how weight loss affects magnetic resonance imaging (MRI) of liver fat and volume or liver histology in patients with nonalcoholic steatohepatitis (NASH). We measured changes in liver fat and liver volume associated with weight loss by using an advanced MRI method.

METHODS:

We analyzed data collected from a previous randomized controlled trial in which 43 adult patients with biopsy-proven NASH underwent clinical evaluation, biochemical tests, and MRI and liver biopsy analyses at the start of the study and after 24 weeks. We compared data between patients who did and did not have at least 5% decrease in body mass index (BMI) during the study period.

RESULTS:

Ten of 43 patients had at least a 5% decrease in BMI during the study period. These patients had a significant decrease in liver fat, which was based on MRI proton density fat fraction estimates (18.3% ± 7.6% to 13.6% ± 13.6%, P = .03), a relative 25.5% reduction. They also had a significant decrease in liver volume (5.3%). However, no significant changes in levels of alanine aminotransferase or aspartate aminotransferase were observed with weight loss. Thirty-three patients without at least 5% decrease in BMI had insignificant increases in estimated liver fat fraction and liver volume.

CONCLUSIONS:

A reduction in BMI of at least 5% is associated with significant decrease in liver fat and volume in patients with biopsy-proven NASH. These data should be considered in assessing effect size in studies of patients with nonalcoholic fatty liver disease or obesity that use MRI-estimated liver fat and volume as end points.

KEYWORDS:

Biomarker; Noninvasive; Response to Treatment; Steatosis

PMID:
25218667
PMCID:
PMC4333065
DOI:
10.1016/j.cgh.2014.08.039
[Indexed for MEDLINE]
Free PMC Article

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