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Arterioscler Thromb Vasc Biol. 2014 Nov;34(11):2387-93. doi: 10.1161/ATVBAHA.114.302523. Epub 2014 Sep 4.

Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease.

Author information

1
From the Heart Institute, Cincinnati Children's Hospital Medical Center, OH (K.E.Y.); Departments of Medicine, Physiology and Bioengineering, University of California, Los Angeles (L.L.D.); Center for Perioperative Genomics, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA (S.C.B.); MCRI Center for Translational Genomics, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (G.S.H.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Center, Orlando, FL (D.A.T.); Bioengineering Department, University of Washington, Seattle (C.M.G.); Department of Medicine, Section of Cardiology, University of Chicago, IL (M.A.H.-B.); Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN (D.P.M.); Biochemistry and Molecular Biology, Rutgers-NJ Medical School, Newark (M.B.R.); Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (M.M.S.); VA Connecticut Healthcare System, West Haven (M.M.S.); and Center of Excellence in Vascular Biology, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.).
2
From the Heart Institute, Cincinnati Children's Hospital Medical Center, OH (K.E.Y.); Departments of Medicine, Physiology and Bioengineering, University of California, Los Angeles (L.L.D.); Center for Perioperative Genomics, Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA (S.C.B.); MCRI Center for Translational Genomics, Tufts Medical Center and Tufts University School of Medicine, Boston, MA (G.S.H.); Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Center, Orlando, FL (D.A.T.); Bioengineering Department, University of Washington, Seattle (C.M.G.); Department of Medicine, Section of Cardiology, University of Chicago, IL (M.A.H.-B.); Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN (D.P.M.); Biochemistry and Molecular Biology, Rutgers-NJ Medical School, Newark (M.B.R.); Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT (M.M.S.); VA Connecticut Healthcare System, West Haven (M.M.S.); and Center of Excellence in Vascular Biology, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (E.A.). eaikawa@partners.org.

Abstract

Calcific aortic valve disease (CAVD) is increasingly prevalent worldwide with significant morbidity and mortality. Therapeutic options beyond surgical valve replacement are currently limited. In 2011, the National Heart Lung and Blood Institute assembled a working group on aortic stenosis. This group identified CAVD as an actively regulated disease process in need of further study. As a result, the Alliance of Investigators on CAVD was formed to coordinate and promote CAVD research, with the goals of identifying individuals at risk, developing new therapeutic approaches, and improving diagnostic methods. The group is composed of cardiologists, geneticists, imaging specialists, and basic science researchers. This report reviews the current status of CAVD research and treatment strategies with identification of areas in need of additional investigation for optimal management of this patient population.

KEYWORDS:

aortic valve stenosis; calcification; inflammation

PMID:
25189570
PMCID:
PMC4199903
DOI:
10.1161/ATVBAHA.114.302523
[Indexed for MEDLINE]
Free PMC Article

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