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Sci Transl Med. 2014 Sep 3;6(252):252ps9. doi: 10.1126/scitranslmed.3008910.

Arterial innervation in development and disease.

Author information

1
Yale Cardiovascular Research Center, School of Medicine, Yale University, New Haven, CT 06510-3221, USA. Department of Cellular and Molecular Physiology, School of Medicine, Yale University, New Haven, CT 06510-3221, USA. Center for Interdisciplinary Research in Biology (CIRB), Collège de France, Inserm U1050, CNRS UMR 7241, 75005 Paris, France. anne.eichmann@yale.edu.
2
Center for Interdisciplinary Research in Biology (CIRB), Collège de France, Inserm U1050, CNRS UMR 7241, 75005 Paris, France.

Abstract

Innervation of arteries by sympathetic nerves is well known to control blood supply to organs. Recent studies have elucidated the mechanisms that regulate the development of arterial innervation and show that in addition to vascular tone, sympathetic nerves may also influence arterial maturation and growth. Understanding sympathetic arterial innervation may lead to new approaches to treat peripheral arterial disease and hypertension.

PMID:
25186174
DOI:
10.1126/scitranslmed.3008910
[Indexed for MEDLINE]

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