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Adv Healthc Mater. 2015 Feb 18;4(3):361-6. doi: 10.1002/adhm.201400355. Epub 2014 Aug 25.

Modified poly(lactic-co-glycolic acid) nanoparticles for enhanced cellular uptake and gene editing in the lung.

Author information

1
Department of Biomedical Engineering, Yale University, New Haven, CT, 06511, USA.

Abstract

Surface-modified poly(lactic-co-glycolic acid) (PLGA)/poly(β-aminoester)(PBAE)nanoparticles (NPs) have shown great promise in gene delivery. In this work, the pulmonary cellular uptake of these NPs is evaluated and surface-modified PLGA/PBAE NPs are shown to achieve higher cellular association and gene editing than traditional NPs composed of PLGA or PLGA/PBAE blends alone.

KEYWORDS:

cell-penetrating peptide; cellular uptake; gene editing; nanoparticles; pulmonary delivery

PMID:
25156908
PMCID:
PMC4339402
DOI:
10.1002/adhm.201400355
[Indexed for MEDLINE]
Free PMC Article

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