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Cell. 2014 Jul 31;158(3):477-8. doi: 10.1016/j.cell.2014.07.010.

microManaging mitochondrial translation.

Author information

1
Department of Pathology, Yale School of Medicine, New Haven, CT 06437, USA.
2
Department of Pathology, Yale School of Medicine, New Haven, CT 06437, USA; Department of Genetics, Yale School of Medicine, New Haven, CT 06437, USA. Electronic address: gerald.shadel@yale.edu.

Abstract

Regulation of gene expression in mammalian mitochondria by microRNAs is reported by Zhang et al. During muscle cell differentiation, localization of a miRNA is increased within mitochondria, where it interacts with Ago2 to selectively activate translation of mtDNA-encoded mRNAs. The findings represent a new mitochondrial regulatory pathway and a potentially powerful means to purposefully manipulate mtDNA expression.

PMID:
25083863
DOI:
10.1016/j.cell.2014.07.010
[Indexed for MEDLINE]
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