Format

Send to

Choose Destination
Vasc Cell. 2014 Jul 9;6:14. doi: 10.1186/2045-824X-6-14. eCollection 2014.

Flow-regulated lymphatic vasculature development and signaling.

Author information

1
Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, 300 George St, New Haven, CT 06520, USA.
2
Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, 300 George St, New Haven, CT 06520, USA ; Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA.

Abstract

The role of blood flow in regulating signaling pathways and gene expression in the blood vasculature is well known. Recent studies have identified equally important roles of flow-mediated signaling in the lymphatic circulation including control of lymphatic vascular growth, remodeling, regeneration and maintenance of the lymphatic fate. In this review, we summarize these advances focusing on the role of fluid dynamics in control of lymphatic vasculature formation.

KEYWORDS:

Flow; Lymphatic endothelial cells; Lymphatic vascular development; Shear stress; Signaling

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center