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Mol Cell Biol. 2014 Oct;34(20):3780-7. doi: 10.1128/MCB.00871-14. Epub 2014 Jul 21.

Virus meets host microRNA: the destroyer, the booster, the hijacker.

Author information

1
Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut, USA Howard Hughes Medical Institute Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
2
Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut, USA Howard Hughes Medical Institute Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA joan.steitz@yale.edu.

Abstract

Virus-host interactions highlight key regulatory steps in the control of gene expression. MicroRNAs (miRNAs) are small noncoding RNAs that regulate protein production via base pairing with mRNAs. Both DNA and RNA viruses have evolved mechanisms to degrade, boost, or hijack cellular miRNAs to benefit the viral life cycle. This minireview focuses on recent discoveries in virus-host miRNA interactions.

PMID:
25047834
PMCID:
PMC4187717
DOI:
10.1128/MCB.00871-14
[Indexed for MEDLINE]
Free PMC Article

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