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Exp Dermatol. 2014 Oct;23(10):757-9. doi: 10.1111/exd.12503.

Novel gene identified in an exome-wide association study of tanning dependence.

Author information

1
Yale School of Public Health, New Haven, CT, USA; Yale Cancer Center, New Haven, CT, USA.

Abstract

Growing evidence suggests that some individuals may exhibit symptoms of dependence to ultraviolet light, a known carcinogen, in the context of tanning. Genetic associations with tanning dependence (TD) have not yet been explored. We conducted an exome-wide association study in 79 individuals who exhibited symptoms of TD and 213 individuals with volitional exposure to ultraviolet light, but who were not TD based on three TD scales. A total of 300 000 mostly exomic single nucleotide polymorphisms primarily in coding regions were assessed using an Affymetrix Axiom array. We performed a gene burden test with Bonferroni correction for the number of genes examined (P < 0.05/14 904 = 3.36 × 10(-6) ). One gene, patched domain containing 2 (PTCHD2), yielded a statistically significant P-value of 2.5 × 10(-6) (OR = 0.27) with fewer individuals classified as TD having a minor allele at this locus. These results require replication, but are the first to support a specific genetic association with TD.

KEYWORDS:

PTCHD2 gene; genetic association; tanning dependence

PMID:
25041255
PMCID:
PMC4204712
DOI:
10.1111/exd.12503
[Indexed for MEDLINE]
Free PMC Article
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