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Trends Biochem Sci. 2014 Aug;39(8):341-3. doi: 10.1016/j.tibs.2014.06.003. Epub 2014 Jul 12.

Noncoding RNAs in the regulation of DNA replication.

Author information

1
Yale Stem Cell Center and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA.
2
Yale Stem Cell Center and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: haifan.lin@yale.edu.

Abstract

Noncoding RNAs (ncRNAs) have crucial roles in epigenetic, transcriptional, and post-transcriptional regulation. Recent studies have begun to reveal a role of ncRNAs in DNA replication. Here, we review the roles of ncRNAs in regulating different aspects of DNA replication in prokaryotic and eukaryotic systems. We speculate that ncRNAs might function to guide the origin recognition complex (ORC) to chromosomal DNA during replication initiation in higher eukaryotes.

KEYWORDS:

DNA replication; ORC; miRNA; noncoding RNA; primer

PMID:
25027733
PMCID:
PMC4265214
DOI:
10.1016/j.tibs.2014.06.003
[Indexed for MEDLINE]
Free PMC Article
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