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Structure. 2014 Jul 8;22(7):935-6. doi: 10.1016/j.str.2014.06.004.

The HIV-1 Env trimer in HD.

Author information

1
Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA.
2
Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA. Electronic address: walther.mothes@yale.edu.

Abstract

Understanding the structure of the native HIV-1 envelope spike protein is critical for the development of vaccines and antiviral therapies. In this issue of Structure, Guttman and colleagues use hydrogen-deuterium exchange (HDX) to provide new insights into the structure of the HIV-1 Env trimer and enhance our understanding of how HIV-1 Env is activated for virus fusion.

PMID:
25007222
PMCID:
PMC4094347
DOI:
10.1016/j.str.2014.06.004
[Indexed for MEDLINE]
Free PMC Article

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