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Angew Chem Int Ed Engl. 2014 Jul 21;53(30):7892-5. doi: 10.1002/anie.201404320. Epub 2014 Jun 25.

Broad-spectrum catalysts for the ambient temperature anti-Markovnikov hydration of alkynes.

Author information

1
Department of Chemistry, Yale University, 225 Prospect Street, New Haven, CT 06520-8107 (USA).

Abstract

Anti-Markovnikov alkyne hydration provides a valuable route to aldehydes. Half-sandwich ruthenium complexes ligated by 5,5'-bis(trifluoromethyl)-2,2'-bipyridine are remarkably active for this transformation. In the presence of 2 mol % metal, a wide range of functionalized aliphatic and aromatic alkynes are hydrated in high yield at ambient temperature.

KEYWORDS:

alkynes; bipyridines; homogeneous catalysis; hydration; ruthenium

PMID:
24964738
DOI:
10.1002/anie.201404320

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