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Int Immunol. 2014 Sep;26(9):495-9. doi: 10.1093/intimm/dxu066. Epub 2014 Jun 19.

Inflammasomes and intestinal homeostasis: regulating and connecting infection, inflammation and the microbiota.

Author information

1
Department of Immunobiology, School of Medicine, Yale University, The Anlyan Center, 300 Cedar Street S560, S570 New Haven, CT 06519, USA.
2
Department of Immunobiology, School of Medicine, Yale University, The Anlyan Center, 300 Cedar Street S560, S570 New Haven, CT 06519, USA Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA.
3
Department of Immunobiology, School of Medicine, Yale University, The Anlyan Center, 300 Cedar Street S560, S570 New Haven, CT 06519, USA Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA richard.flavell@yale.edu.

Abstract

Inflammasomes are large cytosolic protein complexes that detect infection and stress-associated signals and promote immediate inflammatory responses. In the intestine, activation of the inflammasome leads to an inflammatory response that is important for controlling enteric infections but can also result in pathological tissue damage. Recent studies have suggested that the inflammasome also regulates intestinal homeostasis through its effects on the intestinal microbiota. Notably, many conflicting studies have been published regarding the effect of inflammasome deficiencies on intestinal homeostasis. Here, we attempt to reconcile these contrasting data by highlighting the many ways that the inflammasome contributes to intestinal homeostasis and pathology and exploring the potential role of alterations in the microbiota in these conflicting studies.

KEYWORDS:

IBD; infection; inflammasome; intestine; microbiota

PMID:
24948595
PMCID:
PMC4200027
DOI:
10.1093/intimm/dxu066
[Indexed for MEDLINE]
Free PMC Article

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