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Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1831-7. doi: 10.1161/ATVBAHA.114.303217. Epub 2014 Jun 12.

Receptor tyrosine kinases endocytosis in endothelium: biology and signaling.

Author information

1
From the Department of Cell Biology, and Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT.
2
From the Department of Cell Biology, and Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT. michael.simons@yale.edu.

Abstract

Receptor tyrosine kinases are involved in regulation of key processes in endothelial biology, including proliferation, migration, and angiogenesis. It is now generally accepted that receptor tyrosine kinase signaling occurs intracellularly and on the plasma membrane, although many important details remain to be worked out. Endocytosis and subsequent intracellular trafficking spatiotemporally regulate receptor tyrosine kinase signaling, whereas signaling endosomes provide a platform for the compartmentalization of signaling events. This review summarizes recent advances in our understanding of endothelial receptor tyrosine kinase endocytosis and signaling using vascular endothelial growth factor receptor-2 as a paradigm.

KEYWORDS:

endocytosis; fibroblast growth factor receptor 1; myosin-VI; neuropilin; receptor, epidermal growth factor; synectin; vascular endothelial growth factor receptor-2

PMID:
24925972
PMCID:
PMC4141018
DOI:
10.1161/ATVBAHA.114.303217
[Indexed for MEDLINE]
Free PMC Article

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