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Neuromuscul Disord. 2014 Jul;24(7):604-10. doi: 10.1016/j.nmd.2014.04.009. Epub 2014 May 4.

Four-year longitudinal study of clinical and functional endpoints in sporadic inclusion body myositis: implications for therapeutic trials.

Author information

1
Institut de Myologie, GH Pitié-Salpêtrière, Paris, France. Electronic address: jy.hogrel@institut-myologie.org.
2
Institut de Myologie, GH Pitié-Salpêtrière, Paris, France; Université Pierre et Marie Curie, Assistance Publique - Hôpitaux de Paris, GH Pitié-Salpêtrière, Service de Médecine Interne 1, Paris, France.
3
Institut de Myologie, GH Pitié-Salpêtrière, Paris, France.
4
Université Pierre et Marie Curie, Assistance Publique - Hôpitaux de Paris, GH Pitié-Salpêtrière, Service de Médecine Interne 1, Paris, France.

Abstract

Natural history studies in sporadic inclusion body myositis are of fundamental interest for future therapeutic trials. Previous works have demonstrated the particular relevance of knee extension strength in the follow-up of this disease. This work aimed to extend a preceding natural history over 9 months to a four year period. Thirteen patients were assessed using clinical and functional scales and dynamometry. Except wrist extension torque and manual muscle testing composite score, all the measurements presented a significant decline. The most important changes were observed for knee extension and ankle flexion and extension. The relative change in knee extension strength correlated with the level of strength at baseline. A non-linear correlation was found between 6-minute walk distance and knee extension strength. This study confirms that knee extension strength is particularly relevant to follow patients with sporadic inclusion body myositis. It also shows that a strength loss does not have linear consequences on motor ability. Finally strength and motor ability are complementing each other in the understanding of disease progression.

KEYWORDS:

Dynamometry; Inclusion body myositis; Natural history; Outcome measures; Strength

PMID:
24857365
DOI:
10.1016/j.nmd.2014.04.009
[Indexed for MEDLINE]

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