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Diabetes Care. 2014 Jun;37(6):1741-4. doi: 10.2337/dc13-2612. Epub 2014 Apr 2.

Evolution of abnormal plasma glucagon responses to mixed-meal feedings in youth with type 1 diabetes during the first 2 years after diagnosis.

Author information

1
Section of Endocrinology, Department of Pediatrics, Yale University School of Medicine, New Haven, CT.
2
Endocrinology and Diabetes, Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA.
3
Pediatric Endocrinology, Nemours Children's Clinic, Jacksonville, FL.
4
Division of Pediatric Endocrinology and Diabetes, Stanford University, Stanford, CA.
5
Department of Pediatrics, Washington University in St. Louis, St. Louis, MO.
6
Jaeb Center for Health Research, Tampa, FL.
7
Jaeb Center for Health Research, Tampa, FL direcnet@jaeb.org.

Abstract

OBJECTIVE:

To examine the evolution of the dysregulated glucagon responses to mixed-meal tolerance tests (MMTTs) in youth with recent-onset type 1 diabetes (T1D).

RESEARCH DESIGN AND METHODS:

MMTTs were performed in 25 youth (9-18 years of age) with 1.5-12 months disease duration (year 1); 22 subjects were restudied 1 year later (year 2). Twenty nondiabetic (ND) control children were also studied.

RESULTS:

In T1D children, MMTT-stimulated increases in glucagon were significantly greater than that in ND children (median increments: year 1, 21 pg/mL [16-30]; year 2, 25 pg/mL [16-30]; ND, 9 pg/mL [5-16]; P = 0.001 and P < 0.001, respectively).

CONCLUSIONS:

In comparison with ND control children, exaggerated plasma glucagon responses to mixed-meal feedings are observed in youth with T1D within the first 2 years of diagnosis. Further studies to determine whether suppression of these abnormal responses may help to improve glycemic control are warranted.

PMID:
24696460
PMCID:
PMC4030093
DOI:
10.2337/dc13-2612
[Indexed for MEDLINE]
Free PMC Article

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