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Cell. 2014 Mar 27;157(1):255-66. doi: 10.1016/j.cell.2014.03.012.

Nuclear Receptors, RXR, and the Big Bang.

Author information

1
Howard Hughes Medical Institute; The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: evans@salk.edu.
2
Howard Hughes Medical Institute; The Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA. Electronic address: davo.mango@utsouthwestern.edu.

Abstract

Isolation of genes encoding the receptors for steroids, retinoids, vitamin D, and thyroid hormone and their structural and functional analysis revealed an evolutionarily conserved template for nuclear hormone receptors. This discovery sparked identification of numerous genes encoding related proteins, termed orphan receptors. Characterization of these orphan receptors and, in particular, of the retinoid X receptor (RXR) positioned nuclear receptors at the epicenter of the "Big Bang" of molecular endocrinology. This Review provides a personal perspective on nuclear receptors and explores their integrated and coordinated signaling networks that are essential for multicellular life, highlighting the RXR heterodimer and its associated ligands and transcriptional mechanism.

PMID:
24679540
PMCID:
PMC4029515
DOI:
10.1016/j.cell.2014.03.012
[Indexed for MEDLINE]
Free PMC Article

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