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Trends Biotechnol. 2014 Apr;32(4):198-209. doi: 10.1016/j.tibtech.2014.02.005. Epub 2014 Mar 12.

Immunotherapy applications of carbon nanotubes: from design to safe applications.

Author information

1
Department of Chemical Engineering, Yale University, PO Box 208284, New Haven, CT, USA. Electronic address: tarek.fahmy@yale.edu.
2
Department of Chemical Engineering, Yale University, PO Box 208284, New Haven, CT, USA; Department of Biomedical Engineering, Yale University, PO Box 208284, New Haven, CT, USA.

Abstract

Carbon nanotubes (CNTs) have the potential to overcome significant challenges related to vaccine development and immunotherapy. Central to these applications is an improved understanding of CNT interactions with the immune system. Unique properties such as high aspect ratio, flexible surface chemistry, and control over structure and morphology may allow for enhanced target specificity and transport of antigens across cell membranes. Although recent work has demonstrated the potential of CNTs to amplify the immune response as adjuvants, other results have also linked their proinflammatory properties to harmful health effects. Here, we review the recent advances of CNT-based immunological research, focusing on current understandings of therapeutic efficacy and mechanisms of immunotoxicology.

KEYWORDS:

cancer; carbon nanotubes; immune system; immunotherapy; toxicity; vaccine

PMID:
24630474
DOI:
10.1016/j.tibtech.2014.02.005
[Indexed for MEDLINE]

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