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Cell Calcium. 2014 Jun;55(6):317-24. doi: 10.1016/j.ceca.2014.02.003. Epub 2014 Feb 12.

Calcium signaling and the secretory activity of bile duct epithelia.

Author information

1
Section of Digestive Diseases, Department of Internal Medicine, Yale University, 333 Cedar Street, PO Box 208019, New Haven, CT 06520-8019, USA.
2
Section of Digestive Diseases, Department of Internal Medicine, Yale University, 333 Cedar Street, PO Box 208019, New Haven, CT 06520-8019, USA. Electronic address: michael.nathanson@yale.edu.

Abstract

Cytosolic calcium (Cai(2+)) is a second messenger that is important for the regulation of secretion in many types of tissues. Bile duct epithelial cells, or cholangiocytes, are polarized epithelia that line the biliary tree in liver and are responsible for secretion of bicarbonate and other solutes into bile. Cai(2+) signaling plays an important role in the regulation of secretion by cholangiocytes, and this review discusses the machinery involved in the formation of Ca(2+) signals in cholangiocytes, along with the evidence that these signals regulate ductular secretion. Finally, this review discusses the evidence that impairments in cholangiocyte Ca(2+) signaling play a primary role in the pathogenesis of cholestatic disorders, in which hepatic bile secretion is impaired.

KEYWORDS:

Calcium; Cholangiocytes; InsP3 receptors; Secretion

PMID:
24612866
PMCID:
PMC4058373
DOI:
10.1016/j.ceca.2014.02.003
[Indexed for MEDLINE]
Free PMC Article

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