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Chin J Cancer. 2014 Mar;33(3):133-9. doi: 10.5732/cjc.013.10243.

Fusion of bone marrow-derived cells with cancer cells: metastasis as a secondary disease in cancer.

Author information

1
Department of Dermatology and the Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut 06520-8059, USA. john.pawelek@yale.edu.

Abstract

This perspective article highlights the leukocyte-cancer cell hybrid theory as a mechanism for cancer metastasis. Beginning from the first proposal of the theory more than a century ago and continuing today with the first proof for this theory in a human cancer, the hybrid theory offers a unifying explanation for metastasis. In this scenario, leukocyte fusion with a cancer cell is a secondary disease superimposed upon the early tumor, giving birth to a new, malignant cell with a leukocyte-cancer cell hybrid epigenome.

PMID:
24589183
PMCID:
PMC3966146
DOI:
10.5732/cjc.013.10243
[Indexed for MEDLINE]
Free PMC Article
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