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Cell Metab. 2014 Jan 7;19(1):6-7. doi: 10.1016/j.cmet.2013.12.010.

NCOA5, IL-6, type 2 diabetes, and HCC: The deadly quartet.

Author information

1
Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, University of California, San Diego, School of Medicine, 9500 Gilman Drive, San Diego, CA 92093, USA.
2
Department of Medicine, University of California, San Diego, School of Medicine, 9500 Gilman Drive, San Diego, CA 92093, USA.
3
Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, University of California, San Diego, School of Medicine, 9500 Gilman Drive, San Diego, CA 92093, USA; Moores UCSD Cancer Center, University of California, San Diego, School of Medicine, 9500 Gilman Drive, San Diego, CA 92093, USA. Electronic address: karinoffice@ucsd.edu.

Abstract

Although type 2 diabetes (T2D) is an established risk factor for hepatocellular carcinoma (HCC), the underlying mechanism that connects these two diseases is unknown. Gao et al. (2013) now suggest that nuclear receptor coactivator 5 (NCOA5) provides a genetic link between the two diseases through its effects on hepatic IL-6 expression.

PMID:
24411937
PMCID:
PMC3947913
DOI:
10.1016/j.cmet.2013.12.010
[Indexed for MEDLINE]
Free PMC Article

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