Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Neurosci. 2014 Jan;15(1):19-31. doi: 10.1038/nrn3641.

Sensory neurons and circuits mediating itch.

Author information

1
Departments of Anesthesiology and Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8051, USA.
2
Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N. Wolfe St, Baltimore, Maryland 21205, USA.
3
Department of Neurosurgery, Johns Hopkins University School of Medicine, 600 N. Wolfe St, Baltimore, Maryland 21287, USA.

Abstract

Chemicals that are used experimentally to evoke itch elicit activity in diverse subpopulations of cutaneous pruriceptive neurons, all of which also respond to painful stimuli. However, itch is distinct from pain: it evokes different behaviours, such as scratching, and originates from the skin or certain mucosae but not from muscle, joints or viscera. New insights regarding the neurons that mediate the sensation of itch have been gained from experiments in which gene expression has been manipulated in different types of pruriceptive neurons as well as from comparisons between psychophysical measurements of itch and the neuronal discharges and other properties of peripheral and central pruriceptive neurons.

PMID:
24356071
PMCID:
PMC4096293
DOI:
10.1038/nrn3641
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center