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Epigenetics. 2014 Jan;9(1):90-100. doi: 10.4161/epi.27536. Epub 2013 Dec 16.

Role of miRNAs and epigenetics in neural stem cell fate determination.

Author information

1
Yale Cardiovascular Research Center; Section of Cardiovascular Medicine; Yale University School of Medicine; New Haven, CT USA.

Abstract

The regulation of gene expression that determines stem cell fate determination is tightly controlled by both epigenetic and posttranscriptional mechanisms. Indeed, small non-coding RNAs such as microRNAs (miRNAs) are able to regulate neural stem cell fate by targeting chromatin-remodeling pathways. Here, we aim to summarize the latest findings regarding the feedback network of epigenetics and miRNAs during embryonic and adult neurogenesis.

KEYWORDS:

cell fate determination; epigenetics machinery; microRNAs; neural stem cells; neurogenesis

PMID:
24342893
PMCID:
PMC3928190
DOI:
10.4161/epi.27536
[Indexed for MEDLINE]
Free PMC Article
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