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Head Neck. 2015 Jan;37(1):1-7. doi: 10.1002/hed.23566. Epub 2014 Feb 12.

Prognostic factors for squamous cell cancer of the parotid gland: an analysis of 2104 patients.

Author information

1
Department of Surgery, Yale University School of Medicine, New Haven, Connecticut.

Abstract

BACKGROUND:

Parotid gland squamous cell cancer (SCC) occurs as metastasis from cutaneous SCC or primary malignancy. There is limited data on incidence, prognosis, and treatment outcomes.

METHODS:

The Surveillance, Epidemiology, and End Results (SEER) database (1988-2009) identified 2104 adult patients with parotid SCC.

RESULTS:

SCC is the second most common parotid malignancy, and its incidence is increasing (annual percentage change 1.7%; ptrend  = .004). Age ≥85 years, tumor size ≥4 cm, extraparenchymal extension, cervical metastases, and distant metastases were independently associated with disease-specific mortality. Compared to no surgery, surgery was associated with improved 5-year disease-specific survival (DSS; 44.4% vs 71.0%; p < .001), whereas radiation alone was similar to no treatment (47.0% vs 41.6%; p = .28).

CONCLUSION:

Surgery and adjuvant radiation therapy (RT) are associated with improved survival compared to radiation alone and no treatment. Patients ≥85 years of age account for nearly 20% of all patients and have a poor prognosis independent of treatment.

KEYWORDS:

parotid; prognosis; salivary; squamous cell carcinoma; survival

PMID:
24339135
DOI:
10.1002/hed.23566
[Indexed for MEDLINE]

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