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Adv Exp Med Biol. 2014;772:41-53. doi: 10.1007/978-1-4614-5915-6_2.

Hypoxia and regulation of cancer cell stemness.

Author information

1
Department of Therapeutic Radiology, Yale School of Medicine, 208040, New Haven, 06520-8040, CT, USA, zhong.yun@yale.edu.

Abstract

Spontaneous tumors often contain heterogeneous populations of tumor cells with different tumor-initiating potentials or cancer cell "stemness." Clonal heterogeneity can be traced to specific locations inside a tumor where clones with different metastatic capabilities are identified, suggesting that the tumor microenvironment can exert a significant effect on the evolution of different clonal populations. Hypoxia is a common feature of tumor microenvironments and has the potential to facilitate malignant progression. This chapter provides a synopsis of hypoxia-regulated pathways implicated in the maintenance of cancer stem cells.

PMID:
24272353
PMCID:
PMC4043215
DOI:
10.1007/978-1-4614-5915-6_2
[Indexed for MEDLINE]
Free PMC Article
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