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Biochem Soc Trans. 2013 Oct;41(5):1131-1136. doi: 10.1042/BST20130112.

NextGen protein design.

Sawyer N#1,2, Speltz EB#1, Regan L1,2,3.

Author information

1
Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06511, U.S.A.
2
Integrated Graduate Program in Physical and Engineering Biology, Yale University, 266 Whitney Avenue, New Haven, CT 06511, U.S.A.
3
Department of Chemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06511, U.S.A.
#
Contributed equally

Abstract

Protein engineering is at an exciting stage because designed protein-protein interactions are being used in many applications. For instance, three designed proteins are now in clinical trials. Although there have been many successes over the last decade, protein engineering still faces numerous challenges. Often, designs do not work as anticipated and they still require substantial redesign. The present review focuses on the successes, the challenges and the limitations of rational protein design today.

PMID:
24059497
PMCID:
PMC4051282
DOI:
10.1042/BST20130112
[Indexed for MEDLINE]
Free PMC Article
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