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EMBO Rep. 2013 Oct;14(10):923-30. doi: 10.1038/embor.2013.131. Epub 2013 Aug 20.

CATP is a critical component of the Neurospora circadian clock by regulating the nucleosome occupancy rhythm at the frequency locus.

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1
Department of Physiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.

Erratum in

  • EMBO Rep. 2014 Oct;15(10):1102.

Abstract

Rhythmic frq transcription is essential for the function of the Neurospora circadian clock. Here we show that there is a circadian histone occupancy rhythm at the frq promoter that is regulated by FREQUENCY (FRQ). Using a combination of forward genetics and genome sequencing, we identify Clock ATPase (CATP) as an essential clock component. Our results demonstrate that CATP associates with the frq locus and other WCC target genes and promotes histone removal at these loci to allow circadian gene transcription. These results indicate that the rhythmic control of histone occupancy at clock genes is critical for circadian clock function.

PMID:
23958634
PMCID:
PMC3807232
DOI:
10.1038/embor.2013.131
[Indexed for MEDLINE]
Free PMC Article
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