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Virology. 2013 Sep;444(1-2):257-62. doi: 10.1016/j.virol.2013.06.020. Epub 2013 Jul 18.

High-risk human papillomavirus E6 inhibits monocyte differentiation to Langerhans cells.

Author information

1
Department of Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.

Abstract

High-risk human papillomaviruses (HPVs) cause a variety of malignancies of the mucosal epithelium. However, the local immune evasion strategies used by HPV-transformed cells remain unclear. Here, we examined the effect of HPV-positive cancer cells on human peripheral blood monocytes, which are precursors of Langerhans cells, key antigen-presenting cells in the squamous epithelium. HPV-positive cervical cancer cells and HPV-E6 expressing cells inhibited monocyte differentiation to Langerhans cells in a contact-dependent manner. Unlike Langerhans cells, monocytes that differentiated in the presence of HPV16 E6-expressing cells exhibited high levels of endocytic activity. Our results suggest that cells infected by high-risk HPV evade immune surveillance by blocking the differentiation of monocytes into competent antigen presenting cells.

KEYWORDS:

Cervical cancer; Dendritic cell; Immune evasion; Monocytes

PMID:
23871219
PMCID:
PMC3755085
DOI:
10.1016/j.virol.2013.06.020
[Indexed for MEDLINE]
Free PMC Article

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